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Randomized Trial of BCG Vaccination at Birth to Low-Birth-Weight Children: Beneficial Nonspecific Effects in the Neonatal Period?
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Zeitschriftentitel: | The Journal of Infectious Diseases |
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Personen und Körperschaften: | , , , , , , , , , , , , |
In: | The Journal of Infectious Diseases, 204, 2011, 2, S. 245-252 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
Oxford University Press
|
Schlagwörter: |
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ElectronicArticle |
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sid-55-col-jstorlife sid-55-col-jstorhealth JSTOR Life Sciences Archive JSTOR Health & General Sciences |
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ai-55-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA5My9pbmZkaXMvamlyMjQw |
finc.record_id |
10.1093/infdis/jir240 |
finc.source_id |
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ris.type |
EJOUR |
rft.atitle |
Randomized Trial of BCG Vaccination at Birth to Low-Birth-Weight Children: Beneficial Nonspecific Effects in the Neonatal Period? |
rft.epage |
252 |
rft.genre |
article |
rft.issn |
0022-1899 |
rft.issue |
2 |
rft.jtitle |
The Journal of Infectious Diseases |
rft.tpages |
7 |
rft.pages |
245-252 |
rft.pub |
Oxford University Press |
rft.date |
2011-07-15 |
x.date |
2011-07-15T00:00:00Z |
rft.spage |
245 |
rft.volume |
204 |
abstract |
<p>Background. Observational studies have suggested that BCG may have nonspecific beneficial effects on survival. Low-birth-weight (LBW) children are not given BCG at birth in Guinea-Bissau; we conducted a randomized trial of BCG at birth (early BCG) vs delayed BCG. Methods, In the period 2004—2008 we recruited 2320 LBW children in Bissau. The children were visited at home at 2, 6, and 12 months of age. With a pretrial infant mortality of 250 per 1000, we hypothesized a 25% reduction in infant mortality for LBW children. Results. Infant mortality was only 101 per 1000 during the trial. In the primary analysis, infant mortality was reduced insignificantly by 17% (mortality rate ratio [MRR] = .83 [.63—1.08]). In secondary analyses, early BCG vaccine was safe with an MRR of .49 (.21—1.15) after 3 days and .55 (.34—.89) after 4 weeks. The reduction in neonatal mortality was mainly due to fewer cases of neonatal sepsis, respiratory infection, and fever. The impact of early BCG on infant mortality was marked for children weighing < 1.5 kg (MRR = .43 [.21—.85]) who had lower coverage for diphtheria-tetanus-pertussis vaccinations. Conclusions. Though early BCG did not reduce infant mortality significantly, it may have a beneficial effect in the neonatal period. This could be important for public health because BCG is often delayed in low-income countries.</p> |
authors |
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[rft.aufirst] => Peter
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doi |
10.1093/infdis/jir240 |
languages |
eng |
url |
http://dx.doi.org/10.1093/infdis/jir240 |
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MAJOR ARTICLES AND BRIEF REPORTS |
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1 |
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author | Aaby, Peter, Roth, Adam, Ravn, Henrik, Napirna, Bitiguida Mutna, Rodrigues, Amabelia, Lisse, Ida Maria, Stensballe, Lone, Diness, Birgitte Rode, Lausch, Karen Rokkedal, Lund, Najaaraq, Biering-Sørensen, Sofie, Whittle, Hilton, Benn, Christine Stabell |
author_facet | Aaby, Peter, Roth, Adam, Ravn, Henrik, Napirna, Bitiguida Mutna, Rodrigues, Amabelia, Lisse, Ida Maria, Stensballe, Lone, Diness, Birgitte Rode, Lausch, Karen Rokkedal, Lund, Najaaraq, Biering-Sørensen, Sofie, Whittle, Hilton, Benn, Christine Stabell, Aaby, Peter, Roth, Adam, Ravn, Henrik, Napirna, Bitiguida Mutna, Rodrigues, Amabelia, Lisse, Ida Maria, Stensballe, Lone, Diness, Birgitte Rode, Lausch, Karen Rokkedal, Lund, Najaaraq, Biering-Sørensen, Sofie, Whittle, Hilton, Benn, Christine Stabell |
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container_issue | 2 |
container_start_page | 245 |
container_title | The Journal of Infectious Diseases |
container_volume | 204 |
description | <p>Background. Observational studies have suggested that BCG may have nonspecific beneficial effects on survival. Low-birth-weight (LBW) children are not given BCG at birth in Guinea-Bissau; we conducted a randomized trial of BCG at birth (early BCG) vs delayed BCG. Methods, In the period 2004—2008 we recruited 2320 LBW children in Bissau. The children were visited at home at 2, 6, and 12 months of age. With a pretrial infant mortality of 250 per 1000, we hypothesized a 25% reduction in infant mortality for LBW children. Results. Infant mortality was only 101 per 1000 during the trial. In the primary analysis, infant mortality was reduced insignificantly by 17% (mortality rate ratio [MRR] = .83 [.63—1.08]). In secondary analyses, early BCG vaccine was safe with an MRR of .49 (.21—1.15) after 3 days and .55 (.34—.89) after 4 weeks. The reduction in neonatal mortality was mainly due to fewer cases of neonatal sepsis, respiratory infection, and fever. The impact of early BCG on infant mortality was marked for children weighing < 1.5 kg (MRR = .43 [.21—.85]) who had lower coverage for diphtheria-tetanus-pertussis vaccinations. Conclusions. Though early BCG did not reduce infant mortality significantly, it may have a beneficial effect in the neonatal period. This could be important for public health because BCG is often delayed in low-income countries.</p> |
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imprint | Oxford University Press, 2011 |
imprint_str_mv | Oxford University Press, 2011 |
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spelling | Aaby, Peter Roth, Adam Ravn, Henrik Napirna, Bitiguida Mutna Rodrigues, Amabelia Lisse, Ida Maria Stensballe, Lone Diness, Birgitte Rode Lausch, Karen Rokkedal Lund, Najaaraq Biering-Sørensen, Sofie Whittle, Hilton Benn, Christine Stabell 0022-1899 Oxford University Press MAJOR ARTICLES AND BRIEF REPORTS http://dx.doi.org/10.1093/infdis/jir240 <p>Background. Observational studies have suggested that BCG may have nonspecific beneficial effects on survival. Low-birth-weight (LBW) children are not given BCG at birth in Guinea-Bissau; we conducted a randomized trial of BCG at birth (early BCG) vs delayed BCG. Methods, In the period 2004—2008 we recruited 2320 LBW children in Bissau. The children were visited at home at 2, 6, and 12 months of age. With a pretrial infant mortality of 250 per 1000, we hypothesized a 25% reduction in infant mortality for LBW children. Results. Infant mortality was only 101 per 1000 during the trial. In the primary analysis, infant mortality was reduced insignificantly by 17% (mortality rate ratio [MRR] = .83 [.63—1.08]). In secondary analyses, early BCG vaccine was safe with an MRR of .49 (.21—1.15) after 3 days and .55 (.34—.89) after 4 weeks. The reduction in neonatal mortality was mainly due to fewer cases of neonatal sepsis, respiratory infection, and fever. The impact of early BCG on infant mortality was marked for children weighing < 1.5 kg (MRR = .43 [.21—.85]) who had lower coverage for diphtheria-tetanus-pertussis vaccinations. Conclusions. Though early BCG did not reduce infant mortality significantly, it may have a beneficial effect in the neonatal period. This could be important for public health because BCG is often delayed in low-income countries.</p> Randomized Trial of BCG Vaccination at Birth to Low-Birth-Weight Children: Beneficial Nonspecific Effects in the Neonatal Period? The Journal of Infectious Diseases |
spellingShingle | Aaby, Peter, Roth, Adam, Ravn, Henrik, Napirna, Bitiguida Mutna, Rodrigues, Amabelia, Lisse, Ida Maria, Stensballe, Lone, Diness, Birgitte Rode, Lausch, Karen Rokkedal, Lund, Najaaraq, Biering-Sørensen, Sofie, Whittle, Hilton, Benn, Christine Stabell, The Journal of Infectious Diseases, Randomized Trial of BCG Vaccination at Birth to Low-Birth-Weight Children: Beneficial Nonspecific Effects in the Neonatal Period?, MAJOR ARTICLES AND BRIEF REPORTS |
title | Randomized Trial of BCG Vaccination at Birth to Low-Birth-Weight Children: Beneficial Nonspecific Effects in the Neonatal Period? |
title_full | Randomized Trial of BCG Vaccination at Birth to Low-Birth-Weight Children: Beneficial Nonspecific Effects in the Neonatal Period? |
title_fullStr | Randomized Trial of BCG Vaccination at Birth to Low-Birth-Weight Children: Beneficial Nonspecific Effects in the Neonatal Period? |
title_full_unstemmed | Randomized Trial of BCG Vaccination at Birth to Low-Birth-Weight Children: Beneficial Nonspecific Effects in the Neonatal Period? |
title_short | Randomized Trial of BCG Vaccination at Birth to Low-Birth-Weight Children: Beneficial Nonspecific Effects in the Neonatal Period? |
title_sort | randomized trial of bcg vaccination at birth to low-birth-weight children: beneficial nonspecific effects in the neonatal period? |
title_unstemmed | Randomized Trial of BCG Vaccination at Birth to Low-Birth-Weight Children: Beneficial Nonspecific Effects in the Neonatal Period? |
topic | MAJOR ARTICLES AND BRIEF REPORTS |
url | http://dx.doi.org/10.1093/infdis/jir240 |