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Age-Dependent Regulation of Chromaffin Cell Proliferation by Growth Factors, Dehydroepiandrosterone (DHEA), and DHEA Sulfate
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Zeitschriftentitel: | Proceedings of the National Academy of Sciences of the United States of America |
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Personen und Körperschaften: | , , , , , , , , |
In: | Proceedings of the National Academy of Sciences of the United States of America, 104, 2007, 6, S. 2007-2012 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
National Academy of Sciences
|
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ElectronicArticle |
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finc.mega_collection |
sid-55-col-jstorlife sid-55-col-jstorhealth JSTOR Life Sciences Archive JSTOR Health & General Sciences |
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ai-55-aHR0cHM6Ly93d3cuanN0b3Iub3JnL3N0YWJsZS8yNTQyNjQxMQ |
finc.source_id |
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ris.type |
EJOUR |
rft.atitle |
Age-Dependent Regulation of Chromaffin Cell Proliferation by Growth Factors, Dehydroepiandrosterone (DHEA), and DHEA Sulfate |
rft.epage |
2012 |
rft.genre |
article |
rft.issn |
0027-8424 |
rft.issue |
6 |
rft.jtitle |
Proceedings of the National Academy of Sciences of the United States of America |
rft.tpages |
5 |
rft.pages |
2007-2012 |
rft.pub |
National Academy of Sciences |
rft.date |
2007-02-06 |
x.date |
2007-02-06T00:00:00Z |
rft.spage |
2007 |
rft.volume |
104 |
abstract |
<p>The adrenal gland comprises two endocrine tissues of distinct origin, the catecholamine-producing medulla and the steroid-producing cortex. The inner adrenocortical zone, which is in direct contact with the adrenomedullary chromaffin cells, produces dehydroepiandrostendione (DHEA) and DHEA sulfate (DHEAS). These two androgens exhibit potential effects on neurogenesis, neuronal survival, and neuronal stem cell proliferation. Unlike the closely related sympathetic neurons, chromaffin cells are able to proliferate throughout life. The aim of this study was to investigate the effect of DHEA and DHEAS on proliferation of bovine chromaffin cells from young and adult animals. We demonstrated that graded concentrations of leukemia inhibitory factor induced proliferation of chromaffin cells from young animals, whereas EGF had no effect. On the contrary, EGF increased the cell proliferation in cells from adult animals, whereas leukemia inhibitory factor was inactive. In both cases, DHEA decreased the proliferative effect induced by the growth factors. Surprisingly, DHEAS enhanced, in a dose-dependent-manner, the effect of growth factors on proliferation in cells from adult animals but not from young animals. Flutamide, ICI 182,780, and RU 486 had no effect on the action of DHEA or DHEAS on chromaffin cell proliferation. These data show that DHEA and its sulfated form, DHEAS, differentially regulate growth-factor-induced proliferation of bovine chromaffin cells. In addition, the sensitivity of chromaffin cells to different growth factors is age-dependent. Furthermore, these two androgens may act through a receptor other than the classical steroid receptors.</p> |
authors |
Array
(
[rft.aulast] => Sicard
[rft.aufirst] => Flavie
)
Array ( [rft.aulast] => Ehrhart-Bornstein [rft.aufirst] => Monika ) Array ( [rft.aulast] => Corbeil [rft.aufirst] => Denis ) Array ( [rft.aulast] => Sperber [rft.aufirst] => Simone ) Array ( [rft.aulast] => Krug [rft.aufirst] => Alexander W. ) Array ( [rft.aulast] => Ziegler [rft.aufirst] => Christian G. ) Array ( [rft.aulast] => Rettori [rft.aufirst] => Valeria ) Array ( [rft.aulast] => McCann [rft.aufirst] => Samuel M. ) Array ( [rft.aulast] => Bornstein [rft.aufirst] => Stefan R. ) |
languages |
eng |
url |
https://www.jstor.org/stable/25426411 |
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1 |
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author | Sicard, Flavie, Ehrhart-Bornstein, Monika, Corbeil, Denis, Sperber, Simone, Krug, Alexander W., Ziegler, Christian G., Rettori, Valeria, McCann, Samuel M., Bornstein, Stefan R. |
author_facet | Sicard, Flavie, Ehrhart-Bornstein, Monika, Corbeil, Denis, Sperber, Simone, Krug, Alexander W., Ziegler, Christian G., Rettori, Valeria, McCann, Samuel M., Bornstein, Stefan R., Sicard, Flavie, Ehrhart-Bornstein, Monika, Corbeil, Denis, Sperber, Simone, Krug, Alexander W., Ziegler, Christian G., Rettori, Valeria, McCann, Samuel M., Bornstein, Stefan R. |
author_sort | sicard, flavie |
collection | sid-55-col-jstorlife, sid-55-col-jstorhealth |
container_issue | 6 |
container_start_page | 2007 |
container_title | Proceedings of the National Academy of Sciences of the United States of America |
container_volume | 104 |
description | <p>The adrenal gland comprises two endocrine tissues of distinct origin, the catecholamine-producing medulla and the steroid-producing cortex. The inner adrenocortical zone, which is in direct contact with the adrenomedullary chromaffin cells, produces dehydroepiandrostendione (DHEA) and DHEA sulfate (DHEAS). These two androgens exhibit potential effects on neurogenesis, neuronal survival, and neuronal stem cell proliferation. Unlike the closely related sympathetic neurons, chromaffin cells are able to proliferate throughout life. The aim of this study was to investigate the effect of DHEA and DHEAS on proliferation of bovine chromaffin cells from young and adult animals. We demonstrated that graded concentrations of leukemia inhibitory factor induced proliferation of chromaffin cells from young animals, whereas EGF had no effect. On the contrary, EGF increased the cell proliferation in cells from adult animals, whereas leukemia inhibitory factor was inactive. In both cases, DHEA decreased the proliferative effect induced by the growth factors. Surprisingly, DHEAS enhanced, in a dose-dependent-manner, the effect of growth factors on proliferation in cells from adult animals but not from young animals. Flutamide, ICI 182,780, and RU 486 had no effect on the action of DHEA or DHEAS on chromaffin cell proliferation. These data show that DHEA and its sulfated form, DHEAS, differentially regulate growth-factor-induced proliferation of bovine chromaffin cells. In addition, the sensitivity of chromaffin cells to different growth factors is age-dependent. Furthermore, these two androgens may act through a receptor other than the classical steroid receptors.</p> |
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format | ElectronicArticle |
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format_de520 | Article, E-Article |
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format_dezwi2 | Article, E-Article |
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geogr_code | not assigned |
geogr_code_person | not assigned |
id | ai-55-aHR0cHM6Ly93d3cuanN0b3Iub3JnL3N0YWJsZS8yNTQyNjQxMQ |
imprint | National Academy of Sciences, 2007 |
imprint_str_mv | National Academy of Sciences, 2007 |
institution | DE-14, DE-D13, DE-15 |
issn | 0027-8424 |
issn_str_mv | 0027-8424 |
language | English |
last_indexed | 2024-03-01T22:42:15.065Z |
match_str | sicard2007agedependentregulationofchromaffincellproliferationbygrowthfactorsdehydroepiandrosteronedheaanddheasulfate |
mega_collection | JSTOR Life Sciences Archive, JSTOR Health & General Sciences |
physical | 2007-2012 |
publishDate | 2007 |
publishDateSort | 2007 |
publisher | National Academy of Sciences |
record_format | ai |
recordtype | ai |
score | 18,864033 |
series | Proceedings of the National Academy of Sciences of the United States of America |
source_id | 55 |
spelling | Sicard, Flavie Ehrhart-Bornstein, Monika Corbeil, Denis Sperber, Simone Krug, Alexander W. Ziegler, Christian G. Rettori, Valeria McCann, Samuel M. Bornstein, Stefan R. 0027-8424 National Academy of Sciences https://www.jstor.org/stable/25426411 <p>The adrenal gland comprises two endocrine tissues of distinct origin, the catecholamine-producing medulla and the steroid-producing cortex. The inner adrenocortical zone, which is in direct contact with the adrenomedullary chromaffin cells, produces dehydroepiandrostendione (DHEA) and DHEA sulfate (DHEAS). These two androgens exhibit potential effects on neurogenesis, neuronal survival, and neuronal stem cell proliferation. Unlike the closely related sympathetic neurons, chromaffin cells are able to proliferate throughout life. The aim of this study was to investigate the effect of DHEA and DHEAS on proliferation of bovine chromaffin cells from young and adult animals. We demonstrated that graded concentrations of leukemia inhibitory factor induced proliferation of chromaffin cells from young animals, whereas EGF had no effect. On the contrary, EGF increased the cell proliferation in cells from adult animals, whereas leukemia inhibitory factor was inactive. In both cases, DHEA decreased the proliferative effect induced by the growth factors. Surprisingly, DHEAS enhanced, in a dose-dependent-manner, the effect of growth factors on proliferation in cells from adult animals but not from young animals. Flutamide, ICI 182,780, and RU 486 had no effect on the action of DHEA or DHEAS on chromaffin cell proliferation. These data show that DHEA and its sulfated form, DHEAS, differentially regulate growth-factor-induced proliferation of bovine chromaffin cells. In addition, the sensitivity of chromaffin cells to different growth factors is age-dependent. Furthermore, these two androgens may act through a receptor other than the classical steroid receptors.</p> Age-Dependent Regulation of Chromaffin Cell Proliferation by Growth Factors, Dehydroepiandrosterone (DHEA), and DHEA Sulfate Proceedings of the National Academy of Sciences of the United States of America |
spellingShingle | Sicard, Flavie, Ehrhart-Bornstein, Monika, Corbeil, Denis, Sperber, Simone, Krug, Alexander W., Ziegler, Christian G., Rettori, Valeria, McCann, Samuel M., Bornstein, Stefan R., Proceedings of the National Academy of Sciences of the United States of America, Age-Dependent Regulation of Chromaffin Cell Proliferation by Growth Factors, Dehydroepiandrosterone (DHEA), and DHEA Sulfate |
title | Age-Dependent Regulation of Chromaffin Cell Proliferation by Growth Factors, Dehydroepiandrosterone (DHEA), and DHEA Sulfate |
title_full | Age-Dependent Regulation of Chromaffin Cell Proliferation by Growth Factors, Dehydroepiandrosterone (DHEA), and DHEA Sulfate |
title_fullStr | Age-Dependent Regulation of Chromaffin Cell Proliferation by Growth Factors, Dehydroepiandrosterone (DHEA), and DHEA Sulfate |
title_full_unstemmed | Age-Dependent Regulation of Chromaffin Cell Proliferation by Growth Factors, Dehydroepiandrosterone (DHEA), and DHEA Sulfate |
title_short | Age-Dependent Regulation of Chromaffin Cell Proliferation by Growth Factors, Dehydroepiandrosterone (DHEA), and DHEA Sulfate |
title_sort | age-dependent regulation of chromaffin cell proliferation by growth factors, dehydroepiandrosterone (dhea), and dhea sulfate |
title_unstemmed | Age-Dependent Regulation of Chromaffin Cell Proliferation by Growth Factors, Dehydroepiandrosterone (DHEA), and DHEA Sulfate |
url | https://www.jstor.org/stable/25426411 |