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JSTOR Life Sciences Archive
JSTOR Health & General Sciences
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rft.atitle Age-Dependent Regulation of Chromaffin Cell Proliferation by Growth Factors, Dehydroepiandrosterone (DHEA), and DHEA Sulfate
rft.epage 2012
rft.genre article
rft.issn 0027-8424
rft.issue 6
rft.jtitle Proceedings of the National Academy of Sciences of the United States of America
rft.tpages 5
rft.pages 2007-2012
rft.pub National Academy of Sciences
rft.date 2007-02-06
x.date 2007-02-06T00:00:00Z
rft.spage 2007
rft.volume 104
abstract <p>The adrenal gland comprises two endocrine tissues of distinct origin, the catecholamine-producing medulla and the steroid-producing cortex. The inner adrenocortical zone, which is in direct contact with the adrenomedullary chromaffin cells, produces dehydroepiandrostendione (DHEA) and DHEA sulfate (DHEAS). These two androgens exhibit potential effects on neurogenesis, neuronal survival, and neuronal stem cell proliferation. Unlike the closely related sympathetic neurons, chromaffin cells are able to proliferate throughout life. The aim of this study was to investigate the effect of DHEA and DHEAS on proliferation of bovine chromaffin cells from young and adult animals. We demonstrated that graded concentrations of leukemia inhibitory factor induced proliferation of chromaffin cells from young animals, whereas EGF had no effect. On the contrary, EGF increased the cell proliferation in cells from adult animals, whereas leukemia inhibitory factor was inactive. In both cases, DHEA decreased the proliferative effect induced by the growth factors. Surprisingly, DHEAS enhanced, in a dose-dependent-manner, the effect of growth factors on proliferation in cells from adult animals but not from young animals. Flutamide, ICI 182,780, and RU 486 had no effect on the action of DHEA or DHEAS on chromaffin cell proliferation. These data show that DHEA and its sulfated form, DHEAS, differentially regulate growth-factor-induced proliferation of bovine chromaffin cells. In addition, the sensitivity of chromaffin cells to different growth factors is age-dependent. Furthermore, these two androgens may act through a receptor other than the classical steroid receptors.</p>
authors Array ( [rft.aulast] => Sicard [rft.aufirst] => Flavie )
Array ( [rft.aulast] => Ehrhart-Bornstein [rft.aufirst] => Monika )
Array ( [rft.aulast] => Corbeil [rft.aufirst] => Denis )
Array ( [rft.aulast] => Sperber [rft.aufirst] => Simone )
Array ( [rft.aulast] => Krug [rft.aufirst] => Alexander W. )
Array ( [rft.aulast] => Ziegler [rft.aufirst] => Christian G. )
Array ( [rft.aulast] => Rettori [rft.aufirst] => Valeria )
Array ( [rft.aulast] => McCann [rft.aufirst] => Samuel M. )
Array ( [rft.aulast] => Bornstein [rft.aufirst] => Stefan R. )
languages eng
url https://www.jstor.org/stable/25426411
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author Sicard, Flavie, Ehrhart-Bornstein, Monika, Corbeil, Denis, Sperber, Simone, Krug, Alexander W., Ziegler, Christian G., Rettori, Valeria, McCann, Samuel M., Bornstein, Stefan R.
author_facet Sicard, Flavie, Ehrhart-Bornstein, Monika, Corbeil, Denis, Sperber, Simone, Krug, Alexander W., Ziegler, Christian G., Rettori, Valeria, McCann, Samuel M., Bornstein, Stefan R., Sicard, Flavie, Ehrhart-Bornstein, Monika, Corbeil, Denis, Sperber, Simone, Krug, Alexander W., Ziegler, Christian G., Rettori, Valeria, McCann, Samuel M., Bornstein, Stefan R.
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container_start_page 2007
container_title Proceedings of the National Academy of Sciences of the United States of America
container_volume 104
description <p>The adrenal gland comprises two endocrine tissues of distinct origin, the catecholamine-producing medulla and the steroid-producing cortex. The inner adrenocortical zone, which is in direct contact with the adrenomedullary chromaffin cells, produces dehydroepiandrostendione (DHEA) and DHEA sulfate (DHEAS). These two androgens exhibit potential effects on neurogenesis, neuronal survival, and neuronal stem cell proliferation. Unlike the closely related sympathetic neurons, chromaffin cells are able to proliferate throughout life. The aim of this study was to investigate the effect of DHEA and DHEAS on proliferation of bovine chromaffin cells from young and adult animals. We demonstrated that graded concentrations of leukemia inhibitory factor induced proliferation of chromaffin cells from young animals, whereas EGF had no effect. On the contrary, EGF increased the cell proliferation in cells from adult animals, whereas leukemia inhibitory factor was inactive. In both cases, DHEA decreased the proliferative effect induced by the growth factors. Surprisingly, DHEAS enhanced, in a dose-dependent-manner, the effect of growth factors on proliferation in cells from adult animals but not from young animals. Flutamide, ICI 182,780, and RU 486 had no effect on the action of DHEA or DHEAS on chromaffin cell proliferation. These data show that DHEA and its sulfated form, DHEAS, differentially regulate growth-factor-induced proliferation of bovine chromaffin cells. In addition, the sensitivity of chromaffin cells to different growth factors is age-dependent. Furthermore, these two androgens may act through a receptor other than the classical steroid receptors.</p>
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imprint National Academy of Sciences, 2007
imprint_str_mv National Academy of Sciences, 2007
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match_str sicard2007agedependentregulationofchromaffincellproliferationbygrowthfactorsdehydroepiandrosteronedheaanddheasulfate
mega_collection JSTOR Life Sciences Archive, JSTOR Health & General Sciences
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spelling Sicard, Flavie Ehrhart-Bornstein, Monika Corbeil, Denis Sperber, Simone Krug, Alexander W. Ziegler, Christian G. Rettori, Valeria McCann, Samuel M. Bornstein, Stefan R. 0027-8424 National Academy of Sciences https://www.jstor.org/stable/25426411 <p>The adrenal gland comprises two endocrine tissues of distinct origin, the catecholamine-producing medulla and the steroid-producing cortex. The inner adrenocortical zone, which is in direct contact with the adrenomedullary chromaffin cells, produces dehydroepiandrostendione (DHEA) and DHEA sulfate (DHEAS). These two androgens exhibit potential effects on neurogenesis, neuronal survival, and neuronal stem cell proliferation. Unlike the closely related sympathetic neurons, chromaffin cells are able to proliferate throughout life. The aim of this study was to investigate the effect of DHEA and DHEAS on proliferation of bovine chromaffin cells from young and adult animals. We demonstrated that graded concentrations of leukemia inhibitory factor induced proliferation of chromaffin cells from young animals, whereas EGF had no effect. On the contrary, EGF increased the cell proliferation in cells from adult animals, whereas leukemia inhibitory factor was inactive. In both cases, DHEA decreased the proliferative effect induced by the growth factors. Surprisingly, DHEAS enhanced, in a dose-dependent-manner, the effect of growth factors on proliferation in cells from adult animals but not from young animals. Flutamide, ICI 182,780, and RU 486 had no effect on the action of DHEA or DHEAS on chromaffin cell proliferation. These data show that DHEA and its sulfated form, DHEAS, differentially regulate growth-factor-induced proliferation of bovine chromaffin cells. In addition, the sensitivity of chromaffin cells to different growth factors is age-dependent. Furthermore, these two androgens may act through a receptor other than the classical steroid receptors.</p> Age-Dependent Regulation of Chromaffin Cell Proliferation by Growth Factors, Dehydroepiandrosterone (DHEA), and DHEA Sulfate Proceedings of the National Academy of Sciences of the United States of America
spellingShingle Sicard, Flavie, Ehrhart-Bornstein, Monika, Corbeil, Denis, Sperber, Simone, Krug, Alexander W., Ziegler, Christian G., Rettori, Valeria, McCann, Samuel M., Bornstein, Stefan R., Proceedings of the National Academy of Sciences of the United States of America, Age-Dependent Regulation of Chromaffin Cell Proliferation by Growth Factors, Dehydroepiandrosterone (DHEA), and DHEA Sulfate
title Age-Dependent Regulation of Chromaffin Cell Proliferation by Growth Factors, Dehydroepiandrosterone (DHEA), and DHEA Sulfate
title_full Age-Dependent Regulation of Chromaffin Cell Proliferation by Growth Factors, Dehydroepiandrosterone (DHEA), and DHEA Sulfate
title_fullStr Age-Dependent Regulation of Chromaffin Cell Proliferation by Growth Factors, Dehydroepiandrosterone (DHEA), and DHEA Sulfate
title_full_unstemmed Age-Dependent Regulation of Chromaffin Cell Proliferation by Growth Factors, Dehydroepiandrosterone (DHEA), and DHEA Sulfate
title_short Age-Dependent Regulation of Chromaffin Cell Proliferation by Growth Factors, Dehydroepiandrosterone (DHEA), and DHEA Sulfate
title_sort age-dependent regulation of chromaffin cell proliferation by growth factors, dehydroepiandrosterone (dhea), and dhea sulfate
title_unstemmed Age-Dependent Regulation of Chromaffin Cell Proliferation by Growth Factors, Dehydroepiandrosterone (DHEA), and DHEA Sulfate
url https://www.jstor.org/stable/25426411