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Immunomodulatory Interactions of Suppressor Cells, Cell-Mediated Immunity, and Cyclophosphamide in Experimental Pyelonephritis

Bibliographic Details
Journal Title: The Journal of Infectious Diseases
Authors and Corporations: Miller, Thomas
In: The Journal of Infectious Diseases, 148, 1983, 6, p. 1096-1100
Type of Resource: E-Article
Language: English
published:
University of Chicago Press
Subjects:
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rft.atitle Immunomodulatory Interactions of Suppressor Cells, Cell-Mediated Immunity, and Cyclophosphamide in Experimental Pyelonephritis
rft.epage 1100
rft.genre article
rft.issn 0022-1899
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rft.jtitle The Journal of Infectious Diseases
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rft.date 1983-12-01
x.date 1983-12-01T00:00:00Z
rft.spage 1096
rft.volume 148
abstract <p>The recent observation that the administration of cyclophosphamide, an immunosuppressive agent, leads to the eradication of bacterial infection in experimental pyelonephritis seems paradoxical. However, cyclophosphamide is also an immunostimulator and, on the basis of its known characteristics, could enhance cell-mediated immunity either by modulation of suppressor cell activity or by depletion of infection-induced suppressor cells. This study examined these alternatives and the relation between suppressor cells, cell-mediated immunity, and cyclophosphamide administration. Cyclophosphamide enhanced the resistance of lymphocytes to the activity of suppressor cells but did not enhance cell-mediated immunity.</p>
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url https://www.jstor.org/stable/30133839
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description <p>The recent observation that the administration of cyclophosphamide, an immunosuppressive agent, leads to the eradication of bacterial infection in experimental pyelonephritis seems paradoxical. However, cyclophosphamide is also an immunostimulator and, on the basis of its known characteristics, could enhance cell-mediated immunity either by modulation of suppressor cell activity or by depletion of infection-induced suppressor cells. This study examined these alternatives and the relation between suppressor cells, cell-mediated immunity, and cyclophosphamide administration. Cyclophosphamide enhanced the resistance of lymphocytes to the activity of suppressor cells but did not enhance cell-mediated immunity.</p>
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spelling Miller, Thomas 0022-1899 University of Chicago Press Original Articles https://www.jstor.org/stable/30133839 <p>The recent observation that the administration of cyclophosphamide, an immunosuppressive agent, leads to the eradication of bacterial infection in experimental pyelonephritis seems paradoxical. However, cyclophosphamide is also an immunostimulator and, on the basis of its known characteristics, could enhance cell-mediated immunity either by modulation of suppressor cell activity or by depletion of infection-induced suppressor cells. This study examined these alternatives and the relation between suppressor cells, cell-mediated immunity, and cyclophosphamide administration. Cyclophosphamide enhanced the resistance of lymphocytes to the activity of suppressor cells but did not enhance cell-mediated immunity.</p> Immunomodulatory Interactions of Suppressor Cells, Cell-Mediated Immunity, and Cyclophosphamide in Experimental Pyelonephritis The Journal of Infectious Diseases
spellingShingle Miller, Thomas, The Journal of Infectious Diseases, Immunomodulatory Interactions of Suppressor Cells, Cell-Mediated Immunity, and Cyclophosphamide in Experimental Pyelonephritis, Original Articles
title Immunomodulatory Interactions of Suppressor Cells, Cell-Mediated Immunity, and Cyclophosphamide in Experimental Pyelonephritis
title_full Immunomodulatory Interactions of Suppressor Cells, Cell-Mediated Immunity, and Cyclophosphamide in Experimental Pyelonephritis
title_fullStr Immunomodulatory Interactions of Suppressor Cells, Cell-Mediated Immunity, and Cyclophosphamide in Experimental Pyelonephritis
title_full_unstemmed Immunomodulatory Interactions of Suppressor Cells, Cell-Mediated Immunity, and Cyclophosphamide in Experimental Pyelonephritis
title_short Immunomodulatory Interactions of Suppressor Cells, Cell-Mediated Immunity, and Cyclophosphamide in Experimental Pyelonephritis
title_sort immunomodulatory interactions of suppressor cells, cell-mediated immunity, and cyclophosphamide in experimental pyelonephritis
topic Original Articles
url https://www.jstor.org/stable/30133839