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Immunomodulatory Interactions of Suppressor Cells, Cell-Mediated Immunity, and Cyclophosphamide in Experimental Pyelonephritis
| Journal Title: | The Journal of Infectious Diseases |
|---|---|
| Authors and Corporations: | |
| In: | The Journal of Infectious Diseases, 148, 1983, 6, p. 1096-1100 |
| Type of Resource: | E-Article |
| Language: | English |
| published: |
University of Chicago Press
|
| Subjects: |
| finc.format |
ElectronicArticle |
|---|---|
| finc.mega_collection |
sid-55-col-jstorlife sid-55-col-jstorhealth JSTOR Life Sciences Archive JSTOR Health & General Sciences |
| finc.id |
ai-55-aHR0cHM6Ly93d3cuanN0b3Iub3JnL3N0YWJsZS8zMDEzMzgzOQ |
| finc.source_id |
55 |
| ris.type |
EJOUR |
| rft.atitle |
Immunomodulatory Interactions of Suppressor Cells, Cell-Mediated Immunity, and Cyclophosphamide in Experimental Pyelonephritis |
| rft.epage |
1100 |
| rft.genre |
article |
| rft.issn |
0022-1899 |
| rft.issue |
6 |
| rft.jtitle |
The Journal of Infectious Diseases |
| rft.tpages |
4 |
| rft.pages |
1096-1100 |
| rft.pub |
University of Chicago Press |
| rft.date |
1983-12-01 |
| x.date |
1983-12-01T00:00:00Z |
| rft.spage |
1096 |
| rft.volume |
148 |
| abstract |
<p>The recent observation that the administration of cyclophosphamide, an immunosuppressive agent, leads to the eradication of bacterial infection in experimental pyelonephritis seems paradoxical. However, cyclophosphamide is also an immunostimulator and, on the basis of its known characteristics, could enhance cell-mediated immunity either by modulation of suppressor cell activity or by depletion of infection-induced suppressor cells. This study examined these alternatives and the relation between suppressor cells, cell-mediated immunity, and cyclophosphamide administration. Cyclophosphamide enhanced the resistance of lymphocytes to the activity of suppressor cells but did not enhance cell-mediated immunity.</p> |
| authors |
Array
(
[rft.aulast] => Miller
[rft.aufirst] => Thomas
)
|
| languages |
eng |
| url |
https://www.jstor.org/stable/30133839 |
| version |
0.9 |
| x.subjects |
Original Articles |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Immunomodulatory+Interactions+of+Suppressor+Cells%2C+Cell-Mediated+Immunity%2C+and+Cyclophosphamide+in+Experimental+Pyelonephritis&rft.date=1983-12-01&genre=article&issn=0022-1899&volume=148&issue=6&spage=1096&epage=1100&pages=1096-1100&jtitle=The+Journal+of+Infectious+Diseases&atitle=Immunomodulatory+Interactions+of+Suppressor+Cells%2C+Cell-Mediated+Immunity%2C+and+Cyclophosphamide+in+Experimental+Pyelonephritis&aulast=Miller&aufirst=Thomas&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1748599594765254656 |
| access_facet | Electronic Resources |
| author | Miller, Thomas |
| author_facet | Miller, Thomas, Miller, Thomas |
| author_sort | miller, thomas |
| branch_nrw | Electronic Resources |
| collection | sid-55-col-jstorlife, sid-55-col-jstorhealth |
| container_issue | 6 |
| container_start_page | 1096 |
| container_title | The Journal of Infectious Diseases |
| container_volume | 148 |
| description | <p>The recent observation that the administration of cyclophosphamide, an immunosuppressive agent, leads to the eradication of bacterial infection in experimental pyelonephritis seems paradoxical. However, cyclophosphamide is also an immunostimulator and, on the basis of its known characteristics, could enhance cell-mediated immunity either by modulation of suppressor cell activity or by depletion of infection-induced suppressor cells. This study examined these alternatives and the relation between suppressor cells, cell-mediated immunity, and cyclophosphamide administration. Cyclophosphamide enhanced the resistance of lymphocytes to the activity of suppressor cells but did not enhance cell-mediated immunity.</p> |
| facet_avail | Online |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-55-aHR0cHM6Ly93d3cuanN0b3Iub3JnL3N0YWJsZS8zMDEzMzgzOQ |
| imprint | University of Chicago Press, 1983 |
| imprint_str_mv | University of Chicago Press, 1983 |
| institution | DE-14, DE-D13 |
| issn | 0022-1899 |
| issn_str_mv | 0022-1899 |
| language | English |
| last_indexed | 2022-11-04T20:42:03.132Z |
| match_str | miller:1983:immunomodulatoryinteractionsofsuppressorcellscellmediatedimmunityandcyclophosphamideinexperimentalpyelonephritis: |
| mega_collection | JSTOR Life Sciences Archive, JSTOR Health & General Sciences |
| physical | 1096-1100 |
| publishDate | 1983 |
| publishDateSort | 1983 |
| publisher | University of Chicago Press |
| recordtype | ai |
| score | 18,68584 |
| series | The Journal of Infectious Diseases |
| source_id | 55 |
| spelling | Miller, Thomas 0022-1899 University of Chicago Press Original Articles https://www.jstor.org/stable/30133839 <p>The recent observation that the administration of cyclophosphamide, an immunosuppressive agent, leads to the eradication of bacterial infection in experimental pyelonephritis seems paradoxical. However, cyclophosphamide is also an immunostimulator and, on the basis of its known characteristics, could enhance cell-mediated immunity either by modulation of suppressor cell activity or by depletion of infection-induced suppressor cells. This study examined these alternatives and the relation between suppressor cells, cell-mediated immunity, and cyclophosphamide administration. Cyclophosphamide enhanced the resistance of lymphocytes to the activity of suppressor cells but did not enhance cell-mediated immunity.</p> Immunomodulatory Interactions of Suppressor Cells, Cell-Mediated Immunity, and Cyclophosphamide in Experimental Pyelonephritis The Journal of Infectious Diseases |
| spellingShingle | Miller, Thomas, The Journal of Infectious Diseases, Immunomodulatory Interactions of Suppressor Cells, Cell-Mediated Immunity, and Cyclophosphamide in Experimental Pyelonephritis, Original Articles |
| title | Immunomodulatory Interactions of Suppressor Cells, Cell-Mediated Immunity, and Cyclophosphamide in Experimental Pyelonephritis |
| title_full | Immunomodulatory Interactions of Suppressor Cells, Cell-Mediated Immunity, and Cyclophosphamide in Experimental Pyelonephritis |
| title_fullStr | Immunomodulatory Interactions of Suppressor Cells, Cell-Mediated Immunity, and Cyclophosphamide in Experimental Pyelonephritis |
| title_full_unstemmed | Immunomodulatory Interactions of Suppressor Cells, Cell-Mediated Immunity, and Cyclophosphamide in Experimental Pyelonephritis |
| title_short | Immunomodulatory Interactions of Suppressor Cells, Cell-Mediated Immunity, and Cyclophosphamide in Experimental Pyelonephritis |
| title_sort | immunomodulatory interactions of suppressor cells, cell-mediated immunity, and cyclophosphamide in experimental pyelonephritis |
| topic | Original Articles |
| url | https://www.jstor.org/stable/30133839 |